This book integrates recent advances in molecular and cell biology of hematopoietic stem cells (HSC) with developments in clinical research in stem cell-based therapy-providing an up-to-date review of novel cytokines and cellular components; animal models; cell preparation, selection, and collection; minimal residual disease and purging; expansion of progenitor cells; allogeneic and autologous transplantation; cellular gene and immunotherapy; and more. Examines key areas for treatment with HSC, including ambulatory care and monitoring, regimen-related toxicities, immunodeficiency and immunization, infection, chronic graft-versus-host and disease, secondary malignancies, and long-term quality of life. Covering stem cell pool regulation and the complex interplay of extrinsic and intrinsic events, Hematopoietic Stem Cell Transplantation summarizes current understanding and development of clinical allogeneic HSC transplantation discusses the use of allogeneic transplantations with reduced conditioning regimen or mini-transplantation considers various strategies for mobilization of HSCs from peripheral blood (PB) of normal donors details detection of bone marrow contamination by tumor cells and removal procedures focuses on efforts to increase the ex vivo transduction efficiency of human HSCs with retroviral vectors explores the effects of growth factor administration and leukapheresis on PB stem cell donors shows the impact of CD34+ cell isolation and the relevance of expansion of HSC from bone marrow for clinical use reveals how minimal residue disease detection assays are crucial for tracking the clinical significance of infused tumor cells employs automated fluorescence image cytometry to study early HSC behavior following seeding Incorporating contributions from over 90 researchers who cite more than 2180 references to encourage continued study,

This book integrates recent advances in molecular and cell biology of hematopoietic stem cells (HSC) with developments in clinical research in stem cell-based therapy-providing an up-to-date review of novel cytokines and cellular components; animal models; cell preparation, selection, and collection; minimal residual disease and purging; expansion of progenitor cells; allogeneic and autologous transplantation; cellular gene and immunotherapy; and more. Examines key areas for treatment with HSC, including ambulatory care and monitoring, regimen-related toxicities, immunodeficiency and immunization, infection, chronic graft-versus-host and disease, secondary malignancies, and long-term quality of life. Covering stem cell pool regulation and the complex interplay of extrinsic and intrinsic events, Hematopoietic Stem Cell Transplantation -summarizes current understanding and development of clinical allogeneic HSC transplantation -discusses the use of allogeneic transplantations with reduced conditioning regimen or mini-transplantation -considers various strategies for mobilization of HSCs from peripheral blood (PB) of normal donors -details detection of bone marrow contamination by tumor cells and removal procedures -focuses on efforts to increase the ex vivo transduction efficiency of human HSCs with retroviral vectors -explores the effects of growth factor administration and leukapheresis on PB stem cell donors -shows the impact of CD34+ cell isolation and the relevance of expansion of HSC from bone marrow for clinical use -reveals how minimal residue disease detection assays are crucial for tracking the clinical significance of infused tumor cells -employs automated fluorescence imagecytometry to study early HSC behavior following seeding Incorporating contributions from over 90 researchers who cite more than 2180 references to encourage continued study, Hematopoietic Stem Cell Transplantation is a blue-chip reference for hematologists, hematopathologists, oncologists, cytotherapists, transplantation immunologists, and molecular biologists.

Blood stem cell transplantation has become an established therapeutic option in the treatment of malignant diseases. At the same time molecular therapeutic approaches (i.e. gene therapy) are promising alternatives to the classical treatment of cancer. The proceedings give an overview of the biology of hematopoietic progenitor cells, peripheral stem cell transplantation in patients with hematological malignancies, recent developments in molecular diagnosis and gene therapeutic concepts, and show that successful future developments require cooperative research connecting basic science with clinical application.

When relations are facilitated by communication technologies such as e-business, food supply networks can improve efficiency, flexibility and effectiveness. However, a lack of trust within such transactions can prevent the integration of e-business into this large, economic sector. Using case studies from European countries, chapters discuss trust-building methods for food networks in an e-business environment. Key issues include the influence of cultural disparity and cross-border transactions upon major product groups such as meat, cereal products and fresh produce.

When relations are facilitated by communication technologies such as e-business, food supply networks can improve efficiency, flexibility and effectiveness. However, a lack of trust within such transactions can prevent the integration of e-business into this large, economic sector. Using case studies from European countries, chapters discuss trust-building methods for food networks in an e-business environment. Key issues include the influence of cultural disparity and cross-border transactions upon major product groups such as meat, cereal products and fresh produce.

Rainer Haas zeigt, dass Usability Engineering eine erhebliche Steigerung der Produktivitat bewirkt, da Arbeitsaufgaben in kurzerer Zeit und unter geringerer psychischer Belastung durchgefuhrt werden. Er behandelt folgende Themen: Erfolgsfaktoren fur das Innovationsmanagement zwischen Unternehmen; Beurteilung der Qualitat von Web-Applikationen; Eignung von E-Collaborationsplattformen zur Produktentwicklung und effizientes Management virtueller Teams.